The Argentine attacking midfielder became one of the MLS’s best midfielders as he featured for the Columbus Crew SC for eight seasons after joining in July 2012; being named the MLS Newcomer of the Year in 2012, leading the Crew SC to the MLS Cup Final in 2015, and becoming only the 19th player in MLS history to register at least 50 goals and 50 assists in MLS. He then joined D.C. United ahead of the 2020 season, making 10 appearances and scoring twice. Overall, Higuaín has registered 57 goals and 63 assists in 203 MLS regular season appearances, in addition to four goals and five assists in 14 playoff matches.
Before arriving in MLS, Higuaín played several seasons in his native Argentina. The midfielder played for Club Atlético Colón for two seasons (2010-2012), Godoy Cruz for one season (2009-2010), Club Atlético Independiente for one season (2008-2009), Nueva Chicago for two seasons (2005-2007) and Club Atlético River Plate for four seasons (2003-2007). He came through the prestigious River Plate academy before signing his first professional contract with the club in 2003.
Higuaín also made stops in Mexico and Turkey, playing for Turkish giants Beşiktaş JK for one season (2007-2008) and Mexican powerhouse Club América for half a season in 2008. With Beşiktaş, he recorded two goals and two assists in 16 appearances. With Club América, he registered two goals and one assist in 22 appearances.